Table 3.
Multivariable analysis results summary
| Outcome | HR (95% CI) | P value |
|---|---|---|
| OS | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.123 (0.984-1.283) | .0857 |
| Relapse∗ | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.211 (1.040-1.410) | .0135 |
| NRM∗ | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.014 (0.840-1.223) | .8863 |
| DFS∗ | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.183 (1.051-1.332) | .0055 |
| Grade II-IV aGVHD | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.110 (0.994-1.240) | .0637 |
| Grade III-IV aGVHD | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 0.925 (0.758-1.130) | .4456 |
| Moderate-to-severe cGVHD, domestic donor center | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 0.647 (0.496-0.843) | .0013 |
| Moderate-to-severe cGVHD, international donor center | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 0.813 (0.633-1.045) | .1063 |
| Moderate-to-severe cGVHD, related donor/no donor center | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.171 (0.860-1.594) | .3161 |
| Moderate-to-severe cGVHD, missing donor center | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 0.245 (0.015-4.030) | .3246 |
| GRFS∗ | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.029 (0.930-1.139) | .5793 |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Primary graft failure | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 1.481 (1.100-1.995) | .0097 |
| Platelet recovery | ||
| Fresh product (ref) | 1.00 | |
| Cryopreserved product | 0.665 (0.518-0.853) | .0013 |
ref., reference group.
OS: age, Karnofsky/Lansky score, HCT-CI, and donor type, and refined DRI. Variables adjusted for within each model.
Relapse: conditioning intensity and refined DRI. Variables adjusted for within each model.
NRM: age, Karnofsky/Lansky score, HCT-CI, and refined DRI. Variables adjusted for within each model.
DFS: age, Karnofsky/Lansky score, HCT-CI, and refined DRI. Variables adjusted for within each model.
Grade II-IV aGVHD: conditioning intensity, cell count, refined DRI, donor type, and GVHD prophylaxis. Variables adjusted for within each model.
Grade III-IV aGVHD: refined DRI and GVHD prophylaxis. Variables adjusted for within each model.
Moderate-to-severe cGVHD: conditioning intensity, donor center location, graft type, GVHD prophylaxis, and the use of in vivo T-cell depletion. Variables adjusted for within each model.
GRFS: Karnofsky/Lansky score, HCT-CI, graft type, refined DRI, and GVHD prophylaxis. Variables adjusted for within each model.
Primary graft failure: HCT-CI, graft type, and GVHD prophylaxis. Variables adjusted for within each model.
Platelet recovery: Karnofsky/Lansky score, HCT-CI, refined DRI, and donor type. Variables adjusted for within each model.
Clinical evidence of relapse only.