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. Author manuscript; available in PMC: 2023 Oct 17.
Published in final edited form as: Semin Fetal Neonatal Med. 2020 Oct 23;25(4):101146. doi: 10.1016/j.siny.2020.101146

Fig. 2.

Fig. 2.

Duration of pregnancy according to whether or not there is intraamniotic inflammation and fetal systemic inflammation (FIRS). The key determinant of pregnancy duration is fetal systemic inflammation regardless of the inflammatory status of the amniotic cavity, as reflected by the procedure-to-delivery interval. The inflammatory status of the amniotic cavity and the fetus was assessed with interleukin-6 (IL-6) concentrations. A white color fetus represents no inflammation [defined as fetal plasma (FP) IL-6 less than 11 pg/mL]. A red color fetus represents fetal systemic inflammation (FP IL-6 greater than 11 pg/mL). The amniotic fluid compartment is either white (no intraamniotic inflammation) or yellow in color (intraamniotic inflammation present). The cut-off value of 7.9 ng/ml was used to define intra-amniotic inflammation. The number of patients in each group is depicted (n). (Reproduced with permission from Romero R, Gomez R, Ghezzi F et al: A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 179:186–193, 1998.).