Table 3.

Genes differentially expressed in fetal inflammatory response syndrome, pediatric sepsis, and endotoxin challenge models of sepsis.

Gene Symbol	Fetal inflammatory response a	Systemic inflammatory response in humans b	Endotoxin challenge c	Pediatric septic shock d
ADM	↑	↑	↑	↑
ALOX5AP	↑	↑	↑	↑
ALPL	↑	↓	↑	↑
ANXA3	↑	↑	↑	↑
BAZ1A	↑	↑	↑	↑
CEACAM1	↑	↑	↑	↑
CKAP4	↑	↑	↑	↑
EMR1	↑	↓	↑	↑
FGR	↑	↓	↑	↑
FLOT1	↑	↑	↑	↑
HLA-DPA1	↓	↓	↓	↓
HLA-DPB1	↓	↓	↓	↓
HLA-DQB1	↓	↓	↓	↓
HP	↑	↑	↑	↑
IL1RN	↑	↑	↑	↑
LIMK2	↑	↑	↑	↑
MAPK14	↑	↑	↑	↑
PGD	↑	↑	↑	↑
PGLYRP1	↑	↑	↑	↑
S100A12	↑	↑	↑	↑
SERPINB1	↑	↑	↑	↑
SLC2A3	↑	↑	↑	↑
SPOCK2	↓	↓	↓	↓
UGCG	↑	↑	↑	↑
UPP1	↑	↑	↑	↑

Arrows indicate direction of change relative to healthy controls.

^aModified with permission from Madsen-Bouterse SA, Romero R, Tarca AL et al. The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol. 2010 Jan; 63(1):73–92.

^bCalvano SE, Xiao W, Richards DR et al. A network-based analysis of systemic inflammation in humans. Nature 2005; 437:1032–1037.

^cTalwar S, Munson PJ, Barb J et al. Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans. Physiol Genomics 2006; 25:203–215.

^dWong HR, Shanley TP, Sakthivel B et al. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007; 30:146–155.