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. 2023 Jul 6;6(10):1340–1346. doi: 10.1021/acsptsci.3c00050

Figure 1.

Figure 1

Activation pathways of TAF and SOF. After entering the cell, TAF and SOF are first hydrolyzed to their alanine metabolites by CES1 and CatA. The alanine metabolites are then metabolized by HINT1 to form the monophosphate products (MP-Nuc). MP-Nuc metabolites are subsequently phosphorylated by native kinases to generate the active metabolites TP-Nuc, namely TFV-DP for TAF and SOF-TP for SOF.

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