Time–concentration
profiles of TAF, SOF, and their metabolites
(TFV, TFV-DP, SOF-MP, and SOF-TP) after incubation with Huh-7, Calu-3,
A549, Caco-2, and Vero-E6 cells. The intracellular concentrations
were measured at 6, 12, and 24 h following incubation with 10 μM
of the prodrugs. Data are presented as the mean ± SD of four
independent experiments.