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Total intracellular accumulations of TAF and SOF and their MP-Nuc and TP-Nuc metabolites in Huh-7, A549, Vero E6, Caco-2, and Calu-3 cells after incubation for 6 h. The total accumulations are the sum of the prodrug and its MP and TP metabolites and are normalized by cellular protein concentrations. ** P < 0.01, n = 4.
