Table 2. Relative Protein Expression Levels of TAF and SOF Activating Enzymes and Transporters in Different Cell Linesa.
Calu-3 | A549 | Caco-2 | Huh-7 | Vero E6 | |
---|---|---|---|---|---|
CES1 | 1.00 | 269 | 106 | 6.75 | ULD |
CatA | 1.00 | 0.67 | 2.03 | 1.00 | 0.84 |
HINT1 | 1.00 | 1.33 | 1.05 | 0.92 | 1.50 |
P-gp | 1.00 | ULD | 48.5 | 17.3 | 26.7 |
OATP1B1 | 1.00 | 2.00 | ULD | 0.60 | ULD |
OATP1B3 | 1.00 | 1.02 | 0.01 | 0.18 | ULD |
Note: The protein expression levels are normalized to that in the Calu-3 cells. ULD: Under the Limit of Detection.