Figure 2.

Common in vitro and in vivo models for studying SARS-CoV-2 viral infection and therapeutics development. (A) In vitro models can be constructed and studied as cells, tissues, or organoids. Common in vitro models are listed. (B) Common in vivo and ex-vivo models include small and large animal models and samples from patients and clinical trials. (C) Flowchart of suggested model based on the purpose and design of SARS-CoV-2 study. (D) Comparison of advantages and disadvantages of in vitro and in vivo models from a cell, tissue, or whole organism level.