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. 2023 Oct 16;21:728. doi: 10.1186/s12967-023-04576-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Transcriptional profiles of the top 5 scoring candidate genes in reference leukocyte transcriptome datasets. The stacked bar graphs show levels of transcript abundance for top 5 scoring M9.2 genes, in: A a dataset comprising isolated leukocyte and hematopoietic progenitor populations contributed to the NCBI gene expression omnibus (GEO) by Novershtern et al. (GSE24759) and B a dataset comprising whole blood and leukocyte populations contributed by Speake et al. (GSE6042459). Abbreviated notations for the Novershtern dataset are as follows: HSC1, Hematopoietic stem cell CD133 + CD34dim; HSC2, Hematopoietic stem cell CD38- CD34 + ; CMP, Common myeloid progenitor; MEP, Megakaryocyte/erythroid progenitor; ERY1, Erythroid CD34 + CD71 + GlyA-; ERY2, Erythroid CD34- CD71 + GlyA-; ERY3, Erythroid CD34- CD71 + GlyA + ; ERY4, Erythroid CD34- CD71lo GlyA + ; ERY5, Erythroid CD34- CD71- GlyA + ; MEGA1, Colony Forming Unit-Megakaryocytic; MEGA2, Megakaryocyte; DENDa1, Plasmacytoid dendritic cell; DENDa2, Myeloid dendritic cell; GMP, Granulocyte/monocyte progenitor; GRAN1, Colony Forming Unit-Granulocyte; GRAN2, Granulocyte (Neutrophilic Metamyelocyte); GRAN3, Granulocyte (Neutrophil); MONO1, Colony Forming Unit-Monocyte; MONO2, Monocyte; BASO1, Basophil; EOS2, Eosinophil; Pre-BCELL2, Early B cell; Pre-BCELL3, Pro-B cell; BCELLa1, Naive B cell; BCELLa2, Mature B cell, able to class switch; BCELLa3, Mature B cell; BCELLa4, Mature B cell, class switched; NKa1, Mature NK cell_CD56- CD16 + CD3-; NKa2, Mature NK cell_CD56 + CD16 + CD3-; NKa3, Mature NK cell CD56- CD16- CD3-; NKa4, NKT cell; TCELL1, CD8 + effector memory RA; TCELL2, Naive CD8 + T cell; TCELL3, CD8 + effector memory cell; TCELL4, CD8 + central memory; TCELL6, Naive CD4 + T cell; TCELL7, CD4 + effector memory cell; TCELL8, CD4 + central memory; Note: NKa1-4 as well as DENDa1 and DENDa2 cells were isolated from adult peripheral blood, other cell populations were isolated from cord blood