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. Author manuscript; available in PMC: 2023 Oct 17.
Published in final edited form as: Nature. 2023 Mar 15;615(7953):742–749. doi: 10.1038/s41586-023-05798-y

Figure 1. Structure of human odorant receptor OR51E2.

Figure 1.

a) Phylogenetic tree of human Class A GPCRs, including both non-olfactory (blue) and odorant receptors. Odorant receptors are further divided into Class I (green) and Class II (orange). OR51E2 is a Class I OR. The phylogenetic distance scale is represented on the left bottom corner (the distance represents 9% differences between sequences). b) Real-time monitoring of cAMP concentration assay showing that human OR51E2 responds to the odorant propionate. Data points are mean ± standard deviation from n = 4 replicates. Cryo-EM density map (c) and ribbon model (d) of active human OR51E2 bound to propionate (yellow spheres). OR51E2 is fused to miniGαs and bound to both Gβγ and the stabilizing nanobody Nb35.