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. 2023 Oct 2;14:1211816. doi: 10.3389/fimmu.2023.1211816

Figure 2.

Figure 2

NSP9 aggravated the tissue damage and death in vivo. (A) Survival of WT (n = 6 per group) infected intraperitoneally with rVSV or rVSV-NSP9 (5 × 108 PFU/mouse) and monitored for 15 days. (B) ELISA assay of IFN-β in blood of WT mice (n = 6) intraperitoneally injected with rVSV or rVSV-NSP9 (5 × 108 PFU/mouse) for 4 days. (C) Microscopy of hematoxylin-and-eosin-stained lung and spleen sections as in (A). (D) Ifnb, Ccl5, Isg15, Tnf and Il6 mRNA levels in the spleens, livers, and lungs of WT mice (n = 6) intraperitoneally injected with rVSV or rVSV-NSP9 (5 × 108 PFU/mouse) for 4 days. Data are representative of at least three independent experiments (Kaplan–Meier analysis in A and mean ± SEM in D). ***P < 0.001, two-tailed unpaired Student’s t-test.