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Ablation of mononuclear phagocytes partially abrogates Sts −/− enhanced clearance phenotype. Eight-week-old male mice were treated with control liposomes (A) or liposomes loaded with clodronate (B) prior to infection with S. aureus USA300 (7.5 × 107 or 7.5 × 104 CFUs/mouse, respectively). Cumulative data compiled from two separate experiments with three to four mice per group. *, P < 0.05; ***, P < 0.005; ****, P < 0.0001 by two-way ANOVA and Sidak multiple-comparison test.
