Table 3.
Some metastasis-related miRNAs reported to be linked to cervical cancer.
miRNA | Expression status (up/down) |
Target | Model (in vitro, in vivo, human) | Cell lines/patient number | Target validation | References |
---|---|---|---|---|---|---|
miR-154-5p | Down | CUL2 | In vitro, in vivo | SiHa | Luciferase reporter assay/Western blotting/qRT-PCR | (180) |
miR-106b-5p | Down | FGF4 | In vitro | SiHa, C-33A, ME-180, MS-751, HCC-94 and HeLa, HEK-293 T, H8 | Luciferase reporter assay/Western blotting/qRT-PCR | (181) |
miR-218 | Down | SFMBT1, DCUNIDI | In vitro | HeLa | luciferase reporter | (182) |
miR-101-5p | Down | CXCL6 | In vitro, in vivo, human | Caski C-4-I, C-33A, SiHa, HcerEpic/50 | Western blotting/qRT-PCR/immunohistochemistry/immunofluorescence | (183) |
miR-215-3p | Down | SOX9 | In vitro, in vivo, human | SiHa, C-33A, C-4-I, Ca-Ski/31 | Luciferase reporter assay/Western blotting/qRT-PCR | (184) |
miR-877 | Down | MACC1 | In vitro, human | HeLa, CaSki, SiHa, C-33A | Luciferase reporter assay/Western blotting/qRT-PCR | (185) |
miR-432 | Down | FN1 | In vitro, human | HeLa, CaSki, SiHa/47 | Luciferase reporter assay/Western blotting/qRT-PCR | (186) |
miR-758 | Down | HMGB3 | In vitro, human | CaSki, HeLa, C33A, SiHa | Luciferase reporter assay/Western blotting/qRT-PCR | (179) |
miR-873 | Down | GLI1 | In vitro, human | C33A, HeLa, SiHa/20 | Luciferase reporter assay/Western blotting/qRT-PCR | (187) |
miR-525-5p | Down | UBE2C | In vitro | SiHa, HeLa, C4-1, Caski, C-33A, SW756 | Luciferase reporter assay/Western blotting/qRT-PCR | (188) |
miR-574-5p | Up | QKI/β-catenin | In vitro, human | SiHa, C-33A, Caski, HeLa/30 | Luciferase reporter assay/Western blotting/qRT-PCR | (189) |
miR-340 | Down | EphA3 | In vitro, human | HeLa/20 | Luciferase reporter assay/Western blotting/qRT-PCR | (120) |
miR-21 | Up | ZEB1 | In vitro, human | SiHa, HeLa/45 | Western blotting/qRT-PCR | (190) |
miR-889-3p | Down | FGFR2 | In vitro, human | HeLa, C-33A, SiHa/49, CaSki | Luciferase reporter assay/Western blotting/qRT-PCR | (191) |
miR-9-5p | Up | SOCS5 | In vitro, in vivo, human | HUVEC, SiHa/44 | Luciferase reporter assay/Western blotting/qRT-PCR | (192) |
miR-543 | Down | TRPM7 | In vitro, in vivo, human | CaSki, SW756, HeLa, SiHa, C-33A/69 | Luciferase reporter assay/Western blotting/qRT-PCR | (193) |
miR-411 | Down | STAT3 | In vitro, human | SiHa, C-33A/45, Ca-Ski, HeLa | Luciferase reporter assay/Western blotting/qRT-PCR | (194) |
miR-362-3p | Down | BCAP31 | In vitro, human | Cell lines/208 | Luciferase reporter assay/Western blotting/qRT-PCR | (195) |
miR-4524b-5p | Up | WTX | In vitro, in vivo, human | HEK-293T, H8/39 | Luciferase reporter assay/Western blotting/qRT-PCR | (196) |
miR -802 | Down | MYLIP | In vitro, in vivo, human | SiHa, CasKi C-33A/35 | Luciferase reporter assay/Western blotting/qRT-PCR | (165) |
miR-29a | Down | DNMT1 | In vitro, human | HeLa SiHa/30, Caski | Luciferase reporter assay/Western blotting/qRT-PCR | (197) |
miR-126 | Down | ZEB1, MMP2, MMP9 | In vitro, human | ME180, SiHa, C-33A, CaSki/30, Hela | Luciferase reporter assay/Western blotting/qRT-PCR | (198) |
miR-199a | Down | B7-H3 | In vitro, in vivo, human | C4-1, CaSki, HeLa, C-33A/30, SiHa | Luciferase reporter assay/Western blotting/qRT-PCR | (169) |
miR-130a | Up | TIMP2, MMP2 | In vitro, human | SiHa, HeLa, C-33A, CaSki/56 | Luciferase reporter assay/Western blotting/qRT-PCR | (199) |
miR-377 | Down | ZEB2 | In vitro, human | CaSki, C-33A, HeLa, SiHa/53 | Luciferase reporter assay/Western blotting/qRT-PCR | (200) |
miR-155-5p | Up | TP53INP1 | In vitro, in vivo, human | C-33 A, C-4-I, SiHa, CaSki/24 | Luciferase reporter assay/Western blotting/qRT-PCR | (201) |
miR-32-5p | Down | HOXB8 | In vitro, human | SiHa/80 | Luciferase reporter assay/Western blotting/qRT-PCR | (202) |
miR-199a-5p | Up | PIAS3 | In vitro, human | C-33A, HeLa, SiHa/70, CaSki | Luciferase reporter assay/Western blotting/qRT-PCR | (203) |
miR-144-3p | Down | MAKP6 | In vitro, in vivo, human | C-33A, HT-3, ME-180, HCC94, MS751/23, HeLa | luciferase reporter assay/Western blotting | (204) |
miR -505-5p | Down | CDK5 | In vitro, human | HT-3, Siha, Hela, C33a, Caski/60 | Luciferase reporter assay/Western blotting/qRT-PCR | (205) |
miR -638 | Down | β-catenin, c-myc | In vitro, human | HeLa, SiHa, CasKi, C33A/196 | Western blotting | (177) |
miR - 15a-5p | Down | YAP1 | In vitro, human | C-33A, HeLa, SiHa, 293T/40, CaSki | Luciferase reporter assay/Western blotting/qRT-PCR | (206) |
miR -374b | Down | FOXM1 | In vitro, human | Hela CaSki/48, SiHa | Luciferase reporter assay/Western blotting/qRT-PCR | (207) |
miR -128 | Down | ITGB5, ITGA5, CEACAM-6, sLex, MMP23, MMP9 | In vitro | CaSKi, HeLa | qRT-PCR | (208) |
miR -484 | Down | MMP14, HNF1A | In vitro, in vivo, human | S12, HeLa/20 | Luciferase reporter assay/Western blotting/qRT-PCR | (209) |
miR -526b | Down | PBX3 | In vitro, in vivo, human | CaSki, Siha, C-33A, HT-3, ME-180/85, Hela | Luciferase reporter assay/Western blotting/qRT-PCR | (210) |
miR-G-10 | Up | PIK3R3 | In vitro, in vivo, human (tissue and serum) | C33A/21, HeLa | Western blotting/qRT-PCR | (211) |
miR-785 | Down | HMGB3 | In vitro, human | HeLa, CaSki, SiHa, C-33A/20 | Luciferase reporter assay/Western blotting/qRT-PCR | (179) |
miR-612 | Down | NOB1 | In vitro, in vivo, human | HeLa, SiHa, C-33A, CaSki/52 | Luciferase reporter assay/Western blotting/qRT-PCR | (212) |
miR-665 | Down | TGFBR1 | In vitro, in vivo, human | Endl/E6E7, H8/33 | Luciferase reporter assay/Western blotting/qRT-PCR | (213) |
miR-96-5p | Up | SFRP4 | In vitro, human | HeLa, SiHa, Me180, Ms751/60 | luciferase reporter Assay/qRT-PCR | (214) |
miR-320c | Down | GABRP | In vitro, human | C-33A/64, HeLa | Luciferase reporter assay/Western blotting/qRT-PCR | (215) |
miR-218 | Down | ROBO1 | In vitro, in vivo, human (serum and tissue) | SiHa, C-33A/140, HeLa | qRT-PCR | (216) |
miR-4429 | Down | RAD51 | In vitro, in vivo | SiHa, HeLa | Luciferase reporter assay/Western blotting/qRT-PCR | (217) |
miR-29b | Down | PTEN | In vitro, in vivo | HeLa, SiHa, Me 180, C-33A, CaSki | Luciferase reporter assay/Western blotting/qRT-PCR | (218) |
miR-362 | Down | BAP31 | In vitro, in vivo, human | 293T/219, HeLa | Luciferase reporter assay/Western blotting/qRT-PCR | (174) |
miR-455-5p | Down | S1PR1 | In vitro, human | Siha, C33A/72 | luciferase reporter Assay/qRT-PCR | (219) |
miR-205 | Up | CHN1 | In vitro, human | SiHa, HeLa, C33A/46 | Luciferase reporter assay/Western blotting/qRT-PCR | (220) |
miR-802 | Down | BTF3 | In vitro, human | HeLa, C-33A, SiHa, ME-180/40 | Luciferase reporter assay/Western blotting/qRT-PCR | (221) |
miR-139-5p | Down | TCF4 | In vitro, human | CaSki, HeLa, SiHa, C-33A/40 | Luciferase reporter assay/Western blotting/qRT-PCR | (222) |