TABLE 1.
Results of studya
| Subject | Group | Mean mosquito salivary gland infectivity grade | Initial parasitemia (parasites/μl) (day) | Cmax (ng/ml) | t1/2 (days) |
|---|---|---|---|---|---|
| 1 | Drug | 3.8 | 453 | 17.2 | |
| 2 | Placebo | 3.6 | 20 (10) | ||
| 3 | Drug | 3.8 | 417 | 15.2 | |
| 4 | Drug | 3.4 | 27 (31) | 244 | 14.4 |
| 5 | Drug | 3.2 | 489 | 13.3 | |
| 6 | Placebo | 3.8 | 88 (10) |
Mosquito infectivity grades were counted on a log scale. Cmax, peak drug concentration in blood; t1/2, elimination half-life.