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. 2022 Mar 26;37:15333175221085066. doi: 10.1177/15333175221085066

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Validation of 6 candidate fSNPs on the HLA-DQA1/DRB1 locus. (A). EMSA showing allele-imbalanced gel shifting with the 6 potential fSNPs on the HLA-DRB1/DQA1 locus using NE from human microglia cell line HMC3. Arrow indicating the allele-imbalanced gel shifting. Risk alleles are underlined. Data for Western blots represents three biologically independent experiments (n = 3). (B). Luciferase reporter assay showing allele-imbalanced luciferase activity with the 6 potential fSNPs in HMC3. RLU: relative luciferase unit. Data for luciferase reporter assay represents 6 biologically independent repeats (n = 6). * P < .05; ** P < .001; and *** P, .0001.