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Sequencing of spontaneous resistant mutants identifies SNPs a in DprE1
| Compound | Mutant | Genome position of SNP | Base change | Amino-acid substitution |
|---|---|---|---|---|
| B18 | 11 resistant mutants | 4236718 | 940 TAC→CAC | Tyr→His |
| TBA-7371 | 6 resistant mutants | 4236718 | 940 TAC→CAC | Tyr→His |
SNPs: single nucleotide polymorphisms.
