TABLE 4.
Preliminary druggability study of compound B18
| Compound | B18 | TBA-7371 |
|---|---|---|
| cLogP | 3.8 | 1.21 |
| PDE6C IC50/µM·L−1 | 81 | 5 |
| A549 IC50/µM·L−1 | >40 | >40 |
| VERO IC50/µM·L−1 | >40 | >40 |
| Water solubility/µg·mL−1 | 21 | 54 |
| Rat plasma protein binding rate | 95.8% | 33.3% |
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