TABLE 2.
Effect of sordarin derivatives on the cell-free protein synthesis assay (IC50s) and on cell growth (MICs)
| Compound |
C. albicans 2005E
|
C. glabrata 2375E
|
C. parapsilosis 2372E
|
C. krusei 2374E
|
C. neoformans 2867E
|
IC50 (μg/ml) for rabbit reticulocytes | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | ||
| Sordarin | 0.01 | 8.0 | 0.2 | >125 | >100 | >125 | >100 | >125 | 0.06 | >125 | >100 |
| GR135402 | 0.2 | 0.015 | 0.8 | >125 | >100 | >125 | >100 | >125 | 0.2 | 0.25 | >100 |
| GM160575 | 0.08 | <0.001 | 0.4 | >125 | >100 | >125 | >100 | >125 | 0.01 | 0.25 | >100 |
| GM191519 | <0.005 | 0.12 | 0.5 | 31.0 | 100 | >125 | 100 | >125 | 0.005 | 125 | >100 |
| GM193663 | <0.005 | <0.001 | 0.02 | 31.0 | >100 | >125 | >100 | >125 | 0.2 | 8.0 | >100 |
| GM211676 | <0.005 | 0.001 | 0.01 | 8.0 | 100 | >125 | 100 | >125 | 0.12 | 1.0 | >100 |