TABLE 3.
Associations between tagging SNPs of CDHR3 and clinical outcomes of our children under the additive model
Odds ratio (95% CI), P value | ||||||||
---|---|---|---|---|---|---|---|---|
SNP (A/a) | Lower RTI | RV-C-associated lower RTI | Wheeze | RV-C-associated wheeze | Asthma exacerbation (AE) | RV-C-associated AE | Oxygen supplement | Systemic corticosteroid |
rs3887998 | 1.01 (0.82–1.24), 0.931 | 1.09 (0.87–1.36), 0.453 | 1.00 (0.81–1.23), 0.981 | 1.04 (0.83–1.30), 0.761 | 0.98 (0.76–1.25), 0.845 | 1.03 (0.78–1.35), 0.845 | 0.79 (0.56–1.12), 0.181 | 0.97 (0.73–1.29), 0.843 |
rs140154310 | 2.06 (0.97–4.37), 0.059 | 2.55 (1.24–5.24), 0.011 a | 2.38 (1.12–5.04), 0.024 | 2.71 (1.32–5.58), 0.007 | 1.88 (0.88–4.03), 0.106 | 1.78 (0.78–4.07), 0.174 | 0.86 (0.26–2.885), 0.805 | 1.72 (0.72–4.13), 0.225 |
rs73195657 | 1.45 (0.97–2.17), 0.074 | 1.47 (0.97–2.23), 0.071 | 1.42 (0.95–2.13), 0.087 | 1.36 (0.89–2.08), 0.151 | 1.11 (0.69–1.78), 0.663 | 0.96 (0.56–1.66), 0.895 | 1.19 (0.65–2.18), 0.576 | 1.39 (0.83–2.32), 0.218 |
rs146004234 | 0.87 (0.50–1.50), 0.608 | 1.00 (0.56–1.81), 0.989 | 0.94 (0.54–1.63), 0.827 | 1.06 (0.59–1.92), 0.836 | 0.88 (0.46–1.70), 0.712 | 1.13 (0.57–2.23), 0.721 | 0.87 (0.37–2.04), 0.742 | 1.04 (0.51–2.12), 0.918 |
rs4730125 | 0.93 (0.76–1.14), 0.495 | 0.96 (0.77–1.19), 0.680 | 0.96 (0.78–1.18), 0.696 | 0.95 (0.76–1.18), 0.630 | 0.78 (0.61–1.00), 0.054 | 0.81 (0.62–1.07), 0.135 | 0.92 (0.67–1.26), 0.596 | 0.80 (0.60–1.07), 0.131 |
rs6967330 | 1.20 (0.89–1.62), 0.230 | 1.35 (0.98–1.85), 0.063 | 1.22 (0.90–1.65), 0.194 | 1.34 (0.97–1.84), 0.073 | 1.08 (0.75–1.54), 0.688 | 1.29 (0.88–1.89), 0.193 | 1.32 (0.86–2.05), 0.208 | 1.45 (0.99–2.12), 0.057 |
rs73195665 | 1.17 (0.78–1.75), 0.452 | 1.18 (0.77–1.80), 0.450 | 1.25 (0.84–1.87), 0.279 | 1.20 (0.78–1.84), 0.401 | 1.14 (0.72–1.81), 0.577 | 1.20 (0.72–1.99), 0.489 | 0.93 (0.49–1.77), 0.821 | 1.69 (1.04–2.74), 0.035 |
rs408223 | 0.93 (0.69–1.25), 0.634 | 0.67 (0.47–0.95), 0.025 | 0.91 (0.67–1.23), 0.537 | 0.72 (0.51–1.02), 0.065 | 1.15 (0.81–1.62), 0.438 | 0.93 (0.63–1.39), 0.736 | 1.25 (0.80–1.95), 0.335 | 1.13 (0.76–1.70), 0.544 |
Statistically significant results are highlighted in bold.