Table 1.

Inclusion/exclusion criteria for the SAFE-ICU study.

Inclusion criteria •Age ≥18 years •Critically ill patients requiring ICU care • Receiving enteral or intravenous therapy of the below-listed antifungals ✓ Fluconazole ✓ Voriconazole ✓ Posaconazole ✓ Isavuconazole ✓ Caspofungin ✓ Anidulafungin ✓ Micafungin ✓ Amphotericin B including prophylaxis indication and? antifungal therapy started in another unit (ward, operating room) for the same infectious episode •Availability of suitable intravenous/intra-arterial access to facilitate sample collection •Written informed consent has been obtained

Exclusion criteria •Age ˂ 18 years. •Pregnancy •Diagnosis with tuberculosis, human immunodeficiency virus, or hepatitis B or C •Consent not obtained

ICU, intensive care unit; SAFE-ICU, Screening Antifungal Exposure in Intensive Care Units.