Table 2.
Antifungal target exposures.
| Antifungal agent | Clinical PK/PD target for efficacy |
|---|---|
| Fluconazole | AUC0-24/MIC ≥55–1006 |
| Voriconazole | Cmin ≥ 1–2 mg/L6 |
| Posaconazole | Cmin >0.5 mg/L (prophylaxis)6 Cmin >1 mg/L (treatment)6 |
| Isavuconazole | Cmin between 2 and 4 mg/L20,21 |
| Echinocandins (caspofungin, anidulafungin, micafungin) | AUC0-24/MIC >3000a, 6 |
| Amphotericin B | Cmax/MIC ≥ 4.522 |
AUC0-24, area under the plasma concentration–time curve from 0 to 24 h; MIC, minimum inhibitory concentration; Cmin, minimum observed plasma concentration; Cmax, maximum observed plasma concentration.
a
In patients receiving micafungin for invasive candidiasis/candidemia.