Table 3.

Data collected in the case report form.

• Demographics ✓ Date of birth ✓ Sex ✓ Height ✓ Weight • Admission details ✓ Date of hospital admission ✓ ICU admission diagnosis ✓ Date and time of ICU admission ✓ APACHE II score ✓ SAPS II score • Organ support ✓ Invasive mechanical ventilation on days of sampling ✓ Renal replacement therapy on days of sampling • Microbiology ✓ Site of infection ✓ Yeast identified •Type of antifungal therapy (empirical, pre-emptive, directed, prophylaxis) •Antibiotics used to treat the current infectious episode that overlaps with the antifungal sampling periods. •Clinical response (resolution, improvement, failure) • Biological data ✓ Albumin ✓ Serum creatinine ✓ AST/ALT ✓ SOFA score • Discharge ✓ Date and time of ICU discharge ✓ ICU discharge status ✓ Date of death ✓ Date and time of hospital discharge ✓ Hospital discharge status ✓ Vital status at 30 days • Renal function data ✓ Serum creatinine • Pharmacokinetics data ✓ Date the study antifungal commenced ✓ Date of occasion ✓ Dose number ✓ Dosing frequency ✓ Route of administration ✓ Infusion duration ✓ Time of dosing and sampling time points

APACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; AST, aspartate aminotransferase; ALT, alanine aminotransferase; SOFA, Sequential Organ Failure Assessment.