Table 4.

Outcomes.

	Conservative oxygen therapy (n = xxxx)	Liberal oxygen therapy (n = xxxx)	Estimate (95% CI)
Primary outcomea
Died at the hospital by day 90- no. (%)	xxx (xx.x)	xxx (xx.x)	Relative risk xx (xx to xx)
			Risk difference xx (xx to xx)
Secondary outcomes
Hours until removed alive from invasive mechanical ventilation			Subhazard ratio of time to extubationc
Number of patients	xxxx	xxxx
Median (IQR)b	xx (xx–xx)	xx (xx–xx)	xx (xx to xx)
Days until discharged alive from ICU			Subhazard ratio of time to ICU dischargec
Number of participants	xxxx	xxxx
Median (IQR)b	xx (xx–xx)	xx (xx–xx)	xx (xx to xx)
Days until discharged alive from hospital			Subhazard ratio of time to hospital dischargec
Number of participants	xxxx	xxxx
Median (IQR)b	xx (xx–xx)	xx (xx–xx)	xx (xx to xx)
Discharged home- no. (%)	xxxx (xx.x)	xxxx (xx.x)	Relative risk xx (xx to xx)
			Risk difference xx (xx to xx)
90-Day mortality- no. (%)	xxxx (xx.x)	xxxx (xx.x)	Relative risk xx (xx to xx)
			Risk difference xx (xx to xx)

Abbreviations: IQR: interquartile range; CI: confidence interval; ICU: intensive care unit.

^aA P value for the primary outcome comparison will be shown in a footnote. The absolute difference between 90-day mortality and corresponding relative risk will be adjusted for site and for the presence or absence of each of the following at randomisation: suspected hypoxic ischaemic encephalopathy following resuscitation from a cardiac arrest and sepsis.

^bDuration of invasive mechanical ventilation and ICU and hospital lengths of stay will be calculated from cumulative incidence functions with mortality regarded as a competing risk.

^cRatios of median time to discharge (or extubation) will be estimated using censored linear regression with logarithm of time to discharge (or extubation) as the dependent variable. Adjustment will be made for the same variables as for the primary outcome.