Table 1.

MiRNA's as prognostic and diagnostic markers

miRNA	Source	Up/down-regulated	Target	Function	Reference
miR-let-7a	Tissue Cell lines	Down	c-Myc	promotes cell growth and invasion, low expression - poor prognosis	[54]
miR-19a,	Serum	Up	TGFBR3	Marker for OSCC epithelial-to-mesenchymal transition and migration	[10]
miR-20a	Serum	Up	STAT3, PTEN	cell proliferation and cancer progression, prognostic marker	[10]
miR-21	Cell lines	Up	AP1, STAT3	Prognostic tool for survival	[55]
	Plasma	Up		circulating miR-21 originates from tumour mass with a positive association with tumour size, local invasion and metastasis	[42]
miR-23a-3p	Tissue Cell lines	Up	FGF2	suppresses cell proliferation prognostic indicator	[56]
miR-24-3p	Saliva	Up	PER1	Diagnostic biomarker, promotes the proliferation of tumour cells	[57]
miR-29b-1-5p	Tissue Cell lines	Up	CDH1	associated with clinical stage, nodal metastasis, poor prognosis, proliferation	[58]
miR-31-5p	Serum	Up	PTEN/AKT	Diagnostic marker	[59]
miR-99a	Serum	Down	-	Poor differentiation and advanced clinical stage - Prognostic marker	[48]
mir-99b-3p mir-100-5p	Tissue	Up	-	Better survival Poor survival	[60]
miR-105	Tissue Cell lines	Up	-	Promotes Progression of cells	[61]
miRNAs-127-3p, 4736, 655-3p	Tissue	Up		Prognostic marker panel for early-stage OSCC	[47]
miR-134	Plasma Saliva	Up	PDCD7 (Programmed Cell Death 7)	Diagnostic marker	[62]
miRNA-137	Tissues Cell lines	Down		Early diagnosis	[45]
miR-139-5p	Tissue Cell lines	Down	CXCR4	poor survival in OSCC	[63]
microRNA-149-3p	Tissue Cell lines	Down	MMP2	Inhibit OSCC cell migration, prognostic biomarker and therapeutic target for OSCC	[64]
miR-155-5p	Tissue	Up	ARID2	proliferation, migration, invasion, EMT of OSCC cells, prognostic marker	[51,65]
miR-183	Tissues	Up		potential marker of clinical stage, a prognostic biomarker of tumour progression	[66]
miR-196a miR-196b	Tissues Cell lines	Up		Low expression - favourable Prognostic marker	[44]
miR-200b-3p	Plasma	Up		Diagnostic biomarker	[67]
miR-204	Tissue	Down	CDC42, RAB22A, EZR	Patient survival, prognostic marker	[53]
miR-222	Tissue Cell lines	Up	CDKN1B	Early diagnostic marker	[68]
miR-423-5p	Saliva	Up	-	OSCC progression and metastasis - diagnostic and prognostic biomarker	[69]
miR-448	Tissue	Up	MPPED2	prognostic marker	[70]
miR-626 miR-5100	Serum	Up	-	Prognostic role, a predictor of survival	[71]
miR-654-5p	Tissue Cell lines	Up	GRAP	promote proliferation, metastasis, chemoresistance of OSCC, diagnostic marker	[72]
MiR-770	Tissue Cell lines	Up	Sirtuin 7 (Sirt7)	promoted OSCC cell migration and invasion, metastasis, poor patient survival	[73]
MiR-4282	Cell lines	Down	LIN28B	inhibits tumour progression, prognostic significance	[74]
miR6870-5p miR7111-5p	Tissue	Down	SRF	prognostic marker, Early detection of OSCC	[75]