Table 1.
Isoxazolines currently available for use in dogs in Canada.
| Product name (market year) | Manufacturer | Route of administration | Isoxazoline | Macrocyclic lactone | Other | Labelled use | Extra-label use |
|---|---|---|---|---|---|---|---|
| Bravecto (2014) | Merck/Intervet | Oral | Fluralaner | N/A | N/A | F, T | D, S, L, O |
| Bravecto topical solution (2018) | Merck/Intervet | Topical | Fluralaner | N/A | N/A | F, T | D, S, L, O |
| Bravecto one (2021) | Merck/Intervet | Oral | Fluralaner | N/A | N/A | F, T | D, S, L, O |
| Credelio (2019) | Elanco | Oral | Lotilaner | N/A | N/A | F, T | D, S |
| Credelio plus (2022) | Elanco | Oral | Lotilaner | Milbemycin oxime | N/A | F, T, R, HT | D, S |
| NexGard (2014) | Boehringer Ingelheim | Oral | Afoxolaner | N/A | N/A | F, T, D | S, O |
| NexGard spectra (2019) | Boehringer Ingelheim | Oral | Afoxolaner | Milbemycin oxime | N/A | F, T, D, HK, R, W, HT | S |
| Simparica (2016) | Zoetis | Oral | Sarolaner | N/A | N/A | F, T | D, S, L, O |
| Simparica trio (2020) | Zoetis | Oral | Sarolaner | Moxidectin | Pyrantel | F, T, D, S, HK, R, HT | L |
D — Demodicosis; F — Fleas; HK — Hookworm; HT — Heartworm; L — Lice infestation; N/A — Not available; O — Otodectic mange; R — Roundworm; S — Sarcoptic mange (scabies); T — Ticks; W — Whipworm.