FIG. 1.

Ofloxacin distribution along head, axillary, and pubic hairs (upper, middle, and lower panels, respectively) of each of five subjects (I to V). Five strands of each hair type were sectioned together into successive 0.5-cm lengths from the dermal end over the length depicted on the abscissa of each graph, and the ofloxacin in each 0.5-cm length was determined. The height of each black column shows the concentration of ofloxacin in the hair length, starting at the dermal end. (I) Hair samples from subject 1 at 1.5 months (1.5M) and 3.5 months (3.5M) after ingestion of 200 mg of ofloxacin only once. (II) Hair samples from subject 2 at 1.5 and 3.5 months after ingestion of ofloxacin at 300 mg/day for 2 days. (III) Hair samples from subject 3 at 1.5 and 3.5 months after ingestion of ofloxacin at 300 mg/day for 2 days. (IV) Hair samples from subject 4 at 2 and 3 months after ingestion of ofloxacin at 300 mg/day for 2 days. (V) Hair samples from subject 5 at 1, 2, and 4 months after ingestion of ofloxacin at 300 mg/day for 2 days. Head hairs were sectioned into successive 1-cm lengths starting at the dermal end, and the amount of ofloxacin in each section was measured.