TABLE 1.
Mean growth rates and peak ofloxacin concentrations in three types of hair
| Subject no. | Hair growth rate in cm/mo (peak drug concn [ng/mg of hair])
|
|||||
|---|---|---|---|---|---|---|
| Head hair
|
Axillary hair
|
Pubic hair
|
||||
| 1–2 mo | 3–4 mo | 1–2 mo | 3–4 mo | 1–2 mo | 3–4 mo | |
| 1 | 1.0 (41.4)b | 1.5 (19.8)b | 0.83 (35.7)b | 0.54 (21.9)b | 0.33 (14.7)b | 0.93, 1.4a (13.8)b |
| 2 | 1.5 (142.6) | 1.2 (48.8) | 0.17 (26.6) | 0.29 (38.8) | 0 (0) | 0.57 (28.9) |
| 3 | 0.83, 1.5a (89.5) | 1.3 (81.3) | 0.17, 1.3a (41.7) | 0.29 (31.2) | 0 (0) | 0.14, 1.0a (27.4) |
| 4 | NDc | 1.7 (61.7) | 0 (0) | 0.67 (24.1) | 0 (0) | 0.53, 1.1a (15.0) |
| 5 | 1.0 (21.6)d | 0.85 (16.3) | 0.18, 0.75a (17.5)d | 0.25 (17.1) | 0.13, 1.0a (16.0)d | 0.31, 1.1a (27.3)d |
| Mean ± SD | 1.2 ± 0.31e,f (73.8 ± 54.0)f | 1.3 ± 0.32 (45.6 ± 27.7) | 0.49 ± 0.48e (24.3 ± 16.4) | 0.54 ± 0.19 (26.6 ± 8.5) | 0.24 ± 0.39e (6.1 ± 8.4) | 0.79 ± 0.42e (22.5 ± 7.4) |
a
The growth rate was calculated for each of two peaks of ofloxacin distribution.
b
The value was normalized to a dose of 600 mg by multiplying the original value by 3 since only subject 1 took a total of 200 mg of ofloxacin instead of 600 mg.
c
ND, not determined.
d
The growth rate and peak concentration were calculated for the hair sample collected 2 months after drug ingestion from subject 5.
e
Values were calculated by using both the first and second peaks.
f
Values were calculated for all of the five subjects except subject 4, who did not provide a head hair sample at 1 to 2 months after drug ingestion.