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. 2023 Sep 13;80(11):2386–2396. doi: 10.1161/HYPERTENSIONAHA.123.21645

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© 2023 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — RNA sequencing of Rosiglitazone treatment during hypoxia/reoxygenation (H/R) in BeWo cells. Volcano (A) depicts the differentially expressed genes in BeWo cells under H/R compared with normoxia (20% O₂) and (B) show differential gene expression profiles of Rosiglitazone-treated cells under H/R conditions relative to drug vehicle (dimethylsulfoxide)-exposed cells. C, A heatmap visualizes the differences of gene isoform expression profiles between the various conditions. The results suggest that Rosiglitazone is capable of rescuing the perturbed gene isoforms in BeWo cells under H/R conditions.