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. 2023 Jul 20;19(3):657–662. doi: 10.4103/1673-5374.377771

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Copyright: © Neural Regeneration Research

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Physical exercise helps maintain memory function and synaptic plasticity in a muse model of epilepsy.

(A) Experimental schedules. (B) No significant change of total distance in the open field (one-way ANOVA followed by Tukey’s post hoc comparisons; F_(2,12) = 0.03448, P = 0.9662). (C) Example animal movement paths in the novel object recognition task. (D) Pilocarpine reduced mouse preference toward the novel object, and exercise prevented this from happening (one-way ANOVA followed by Tukey’s post hoc comparisons; F_(2,12) = 6.193, P = 0.0142). n = 5 mice in each group in B–D. (E) Schematic illustration of the Y-maze task. (F) The Pilo group showed longer latency to enter the novel arm, and exercise training decreased this latency (one-way ANOVA followed by Tukey’s post hoc comparisons; F_(2,18) = 10.97, P = 0.0008). (G) The Pilo group displayed decreased preference for the novel arm, while this effect was absent in the Pilo+Ex group (one-way ANOVA followed by Tukey’s post hoc comparisons; F_(2,18) = 14.08, P = 0.0002). n = 8 mice in each group in F and G. (H) Paired-pulse ratio was elevated in the Pilo group when stimulus intervals were short, and this hyperexcitability was missing after exercise in the Pilo+Ex group (two-way ANOVA with group factor; F_(2,129) = 9.834, P = 0.0001). n = 10 neurons from three mice in each group. (I) Neurons in brain slices from the model group could not maintain LTP. Neurons in brain slices obtained from the Pilo+Ex group displayed normal LTP (two-way ANOVA with group factor; F_(2,1471) = 289.1, P < 0.0001). (J) The fEPSP slope showed similar trends as it was abnormal in slices from the Pilo group and normal in slices from the Pilo+Ex group (one-way ANOVA followed by Tukey’s post hoc comparisons; F_(2,10) = 20.41, P = 0.0003). n = 4 mice in each group in I and J. All data are presented as mean ± SEM. ANOVA: Analysis of variance; Ex: exercise; LTP: long-term potentiation; ns: no significant difference; Pilo: pilocarpine; PPR: paired-pulse ratio.