Table 5.
Summary of the SYRCLE risk of bias
| Study | Random sequence analysis | Baseline characteristics | Allocation concealment | Random housing | Blinding | Random outcome assessment | Binding of outcome assessment | Incomplete outcome data | Selective reporting |
|---|---|---|---|---|---|---|---|---|---|
| Shimizu et al., 2018 | High | High | High | High | High | High | High | Low | Low |
| Wu et al., 2017 | Low | Low | High | Low | High | Low | Low | Low | Low |
| Wu et al., 2016 | Low | Low | High | Low | High | High | Low | Low | Low |
| Chen et al., 2016 | High | Low | High | Low | High | High | Low | Low | Low |
| Hong et al., 2016 | High | Low | High | Low | High | High | High | Low | Low |
| Seifert et al., 2011 | High | Low | High | High | High | High | High | Low | Low |
| Bell et al., 2017 | High | High | High | High | High | Low | Low | Low | Low |
| Choo et al., 2008 | High | Low | High | Low | High | Low | High | Low | Low |
| Wang et al., 2019 | High | Low | High | High | High | High | High | Low | Low |
| Qiu et al., 2015 | High | Low | High | Low | High | High | High | Low | Low |
| Dolan et al., 1980 | High | Low | High | High | High | High | High | Low | Low |
| Choo et al., 2009 | High | Low | High | High | High | High | High | Low | Low |
| Liu et al., 2004 | Low | Low | High | Low | High | High | High | Low | Low |
| Liu et al., 2005 | Low | High | High | High | High | Low | High | Low | Low |
| Yang et al., 2013 | High | High | High | High | High | High | High | Low | Low |
| Guo et al., 2019 | High | Low | High | Low | High | High | High | Low | Low |
| Skinner and Transfeld, 2009 | High | High | High | High | High | High | High | Low | Low |
| Jarzem et al., 1992 | High | High | High | High | High | High | High | Low | Low |
| Kling et al., 1985 | High | Low | High | High | High | High | High | Low | Low |
| Maiman et al., 1989 | High | High | High | High | High | High | High | Low | Low |
| Han et al., 2022 | Low | Low | High | Low | High | Low | High | Low | Low |
| Liang et al., 2022 | Low | Low | High | Low | High | Low | High | Low | Low |
Author’s judgments relating to types of bias for each publication involved the review of selection bias (sequence generation, baseline characteristics and allocation concealment), performance bias (random housing and blinding), detection bias (random outcome assessment and blinding of outcome assessment), attrition bias (incomplete outcome data) and reporting bias (selective outcome reporting). SYRCLE: Systematic Review Centre for Laboratory Animal Experimentation.