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Astrocytes protect dopaminergic neurons.
DT-diaphorase and glutathione transferase M2-2 (GSTM2) prevent the neurotoxic effects of aminochrome. However, GSTM2 that is only expressed in human astrocytes also protects dopaminergic neurons, since astrocytes secrete GSTM2-laden exosomes that penetrate dopaminergic neurons and are released into the cytosol of dopaminergic neurons. Created with ChemDraw. GSH: reduced glutathione; GSTM2: glutathione transferase M2-2; SNCA: alpha-synuclein.
