FIG 1.

Baseline characteristics of the study population. (A) CONSORT diagram of the study depicting eligibility and exclusion criteria, the frequency of patients with ICC and ECC, and the frequency of molecular profiling among patients with advanced disease. (B) Histogram of patients stratified by age of initial diagnosis. The 847-patient cohort was subdivided into groups on the basis of age of initial CCA diagnosis, in increments of 5 years. Patients 50 years and younger represented 15% of the cohort. CCA, cholangiocarcinoma; ECC, extrahepatic cholangiocarcinoma; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma.