FIG 2.

Genomic profiling of young (50 years and younger) versus older (older than 50 years old) patients with CCA. In an analysis of 459 patients who underwent genomic profiling for CCA, FGFR2 fusions, ATM mutations, and BRAF mutations were more commonly seen in younger patients. Starred columns highlight genes with statistically significant differences in rates of alterations present between young and older patients (all P < .05). All gene labels indicate point mutations at the gene with the following exceptions, which include copy number alterations: ATM, CDKN2A, cMET, PIK3CA/PIK3R1, ARID1A, PIK3CA, and SMAD4. CCA, cholangiocarcinoma.