Spectrum of gene alterations targeted with targeted therapies in (A) young (50 years and younger) and (B) older (older than 50 years) patients in our cohort. Among patients who received targeted therapy, the majority in both age groups received targeted therapy directed at FGFR2 fusions or IDH1 mutations. Gene names without the type of alteration indicated refer to mutations of those genes. ALK, anaplastic lymphoma kinase; Amp, amplification; HER2, human epidermal growth factor receptor 2; MET, mesenchymal-epithelial transition factor.