Table 3.
Composition of RTS,S adjuvants
| Adjuvant | Formulation | Alum | MPL | QS21 (Saponin) |
|---|---|---|---|---|
| AS04a | Adult | + | + | − |
| AS03b,c | Adult | − | − | − |
| AS02Ab,e | Adult | − | + | + |
| AS01Bd | Adult | − | + | + |
| AS02Db,e | Paediatric | − | + | + |
| AS01Ed | Paediatric | − | + | + |
+ indicates present; − indicates absent; MPL monophosphoryl lipid A
aAS04 has also been referred to as SBAS4 in published literature
bOil-in-water emulsion-based adjuvant system containing squalene, polysorbate 80 and α-tocopherol
cAS03 has also been referred to as SBAS3 in published literature
dLiposome-based adjuvant system
eAS02 has also been referred to as SBAS2 in published literature