Fig. 3.

Admission nucleosome H3.1 association with 28-day mortality. A Admission level of circulating nucleosomes (day 1–2) in septic shock patients who survived or not. Results are shown as box representing 25th-75th percentile with median and individual values. The Mann–Whitney U test was used for group comparison. B Receiver operating characteristic (ROC) curve of admission nucleosomes (day 1–2) for 28-day mortality. AUC = area under the ROC. C Multivariate analysis (cox proportional hazard model) at admission (day 1–2) for association with mortality. The patients were divided into two groups based on the highest quartile versus the other quartiles for Nu H3.1, Charlson score, and SOFA score