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. 2023 Oct 17;14:6531. doi: 10.1038/s41467-023-42188-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Blood TG level at different time point during TG clearance test (Control n = 6, KSPAPN n = 11). B Blood glycerol level at different time point during TG clearance test (Control n = 6, KSPAPN n = 11). C Blood-free fatty acid level at different time points during the TG clearance test (Control n = 6, KSPAPN n = 11). D ³H-triolein lipid oxidation in tissues, including cortex and medulla, under chow diet conditions (Control n = 7, KSPAPN n = 7). Multiple unpaired two-tailed t-tests with 2-stage linear step-up procedure of BKY correction for multiple comparisons were performed to determine p-values E and F Oxygen consumption rate (OCR) of KSPAPN kidney tissues at basal level and after oligomycin (Oligo), FCCP and rotenone/antimycin-A treatment (Control n = 9, KSPAPN n = 10). G and H Extracellular acidification rate (ECAR) of kidney tissues at basal level, Oligo, FCCP and rotenone/antimycin-A treatment (Control n = 9, KSPAPN n = 10). I and J OCR of KSPAPN kidney tissue in the presence of palmitate with or without etomoxir. (Control pal n = 9, Control pal eto40 n = 10, KSPAPN pal n = 9, KSPAPN pal eto40 n = 9) 1-way ANOVA with 2-stage linear step-up procedure of BKY correction for multiple comparisons were performed to determine p-values for (J). K The ratio of glucose production from primary cultured KSPAPN kidney cortex cells with or without etomoxir treatment (Control n = 5, KSPAPN n = 6). Unpaired two-tailed student’s t-test was performed for statistics. L Blood glucose levels during an OGTT upon 20 mg/kg bodyweight etomoxir treatment (Vehicle n = 8, Etomoxir n = 7). M Blood glucose level in Lactate/pyruvate tolerance test in KSPAPN mice (Control n = 11, KSPAPN n = 10). N Blood glucose levels during a lactate/pyruvate tolerance test in KSPAPN mice (Control n = 9, KSPAPN n = 10). Data are mean ± SEM. 2-way ANOVA with 2-stage linear step-up procedure of BKY correction for multiple comparisons were performed to determine p-values for (E), (F), (G), (H), (L) and (M).