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Proposed mechanism underlying the GP1BA association at the TIMP3 locus. GP1BA (purple hook) is shown as a part of the fully-formed GP1B-IX-V complex on the platelet surface with VWF, one of its major ligands (red). ADAM17 (brown) is shown cleaving GP1BA from the cell surface as part of receptor shedding. TIMP3 (pink) specifically inhibits ADAM17. Created using BioRender.
