Table 2.

Demographics, clinical parameters and outcomes of ICU-admitted patients eligible for VV-ECMO under any criteria (EOLIA, ELSO, NSW, CCSO, Regina-restrictive) compared to patients who met neither criteria.

	Eligible for VV-ECMO (n = 42)	Non-eligible for VV-ECMO (n = 373)	p-value	All patients (n = 415)	Missing observations (N)
Age, median years (IQR)	65 (49–72)	60 (46–71)	0.25	61 (46–71)	0
Male gender, N (%)	33 (78.6%)	217 (58.2%)	0.01	250 (60.2%)	0
Charlson Comorbidity Index, median score (IQR)	1 (0–3)	2 (1–3)	0.33	1 (1–3)	0
Sequential Organ Failure Assessment, median score (IQR)	8 (6–10)	7 (5–9)	0.04	7 (5–9)	0
Clinical Frailty Score (IQR)	3 (2–4)	3 (3–4)	0.02	3 (3–4)	0
Body Mass Index, median kg/m2 (IQR)	29 (26–36)	28 (23–34)	0.09	28 (23–34)	0
Need for dialysis, N (%)	5 (11.9%)	17 (4.6%)	0.06	22 (5.4%)	5
COVID-19, N (%)	7 (16.7%)	41 (11.0%)	0.30	48 (11.6%)	0
Set VT, median mL/kg (IQR)	7.6 (7.1–8.1)	7.8 (7.2–8.3)	0.35	7.8 (7.2–8.3)	12
Actual delivered VT, median mL/kg (IQR)	8.4 (7.8–10.1)	8.5 (7.8–9.8)	0.91	8.5 (7.8–9.7)	4
Prone positioning, N (%)	20 (47.6%)	38 (10.2%)	< 0.001	58 (14.0%)	0
Neuromuscular blockade, N (%)	21 (50.0%)	51 (13.7%)	< 0.001	72 (17.3%)	0
Nitric oxide, N (%)	5 (11.9%)	6 (1.6%)	< 0.001	11 (2.7%)	0
Hospital length of stay, median days (IQR)	17 (8–25)	14 (8–32)	0.73	14 (8–31)	0
ICU length of stay, median days (IQR)	11 (3–19)	6 (4–12)	0.07	7 (4–12)	0
In-hospital mortality, N (%)	23 (54.8%)	113 (30.3%)	0.001	136 (32.8%)	0

CCSO Critical Care Services Ontario, COVID-19 Coronavirus-19, ELSO Extracorporeal Life Support Organization, EOLIA Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Syndrome, ICU intensive care unit, IQR interquartile range, NSW New South Wales, VT tidal volume, VV-ECMO veno-venous extracorporeal membrane oxygenation.