TABLE 1.
Antichlamydial activities of fatty acids
| Fatty acid | Concn (mM)a | Reduction of IFU (log10) at the following times (min):
|
||
|---|---|---|---|---|
| 10 | 5 | 1 | ||
| Capric acid (10:0)b | 20 | ≥5.9c | ≥5.9c | 0.9 |
| 10 | 1.3 | NDd | ND | |
| Lauric acid (12:0) | 20 | ≥4.2e | ≥4.2e | 0.2 |
| 10 | 5.7 | 2.9 | ND | |
| 5 | 3.3 | 0.7 | ND | |
a
Concentration of fatty acids mixed with C. trachomatis and incubated at 37°C for 1, 5, and 10 min. In the mixtures the concentration was reduced by half due to 1:1 dilution with the bacteria.
b
Number of carbon atoms:number of double bonds.
c
No inclusions were detectable in the 10−1 dilution, which was the lowest dilution tested because of toxicity to cell cultures.
d
ND, not done.
e
No inclusions were detectable in the 10−2 dilution, which was the lowest dilution tested due to cytotoxicity.