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Average pharmacokinetic parameters for d4T administered while fasting and after and before a meala
| Food condition | Cmax (ng/ml) | Tmax (h) | AUC0–∞ (ng · h/ml) | t1/2 (h) | CLR (ml/min) | UR (%) |
|---|---|---|---|---|---|---|
| Fasting | 1,439 ± 490 | 0.65 ± 0.28 | 2,527 ± 726 | 1.56 ± 0.27 | 179 ± 76 | 35.2 ± 11.9 |
| 5 min after a meal | 756 ± 166 | 1.73 ± 0.64 | 2,359 ± 537 | 1.55 ± 0.22 | 211 ± 63 | 39.8 ± 11.9 |
| 1 h before a meal | 1,532 ± 673 | 0.75 ± 0.37 | 2,459 ± 721 | 1.67 ± 0.39 | 166 ± 53 | 32.2 ± 7.1 |
Values are means ± standard deviations.
