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. 2023 Jul 5;7(20):6009–6022. doi: 10.1182/bloodadvances.2023010032

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Figure 5. — High effector cytokine secretion by BCMA CAR-Ts compared with that by BCMA CAR-iNKTs and BCMA CAR-ML NK cells. (A) Media from CRS assays shown in Figure 4A was used to measure INF-γ, TNF, and IL-2 effector cytokines. Direct comparison of M-BB BCMA CAR-Ts, CAR-ML NK cells, and CAR-iNKTs (1:1 E:T ratio). (B) A similar experiment shown in panel A from separate donor (0.5:1 E:T ratio) and from the experiment shown in Figure 4B. (C) Effector cytokines secretion in CRS assays from 2 separate donors and either MM.1S-CG or OPM2-CG target cells. Media obtained from the CRS assay shown in Figure 4D-E. (D) rhIL-7-hyFc (1000 ng/mL) was added to standard CRS assays, and effector cytokine levels were measured.