Table 2.
Results of stratified analysis of the thyroid cancer risk estimates according to the oophorectomy condition.
| Combined risk estimate |
Test of heterogeneity |
Publication bias |
||||||
|---|---|---|---|---|---|---|---|---|
| N.b | Value (95% CI) | p | Q | I2% | p | p (Egger test) | p (Begg test) | |
| Any hysterectomy | 13 | 1.64 (1.48–1.81) | <0.0001 | 16.83 | 28.68 | 0.156 | 0.382 | 0.542 |
| Self-reported | 11 | 1.62 (1.43–1.84) | <0.0001 | 16.05 | 37.69 | 0.098 | 0.477 | 0.697 |
| Hospital record | 2 | 1.67 (1.43–1.96) | <0.0001 | 0.76 | 0.00 | 0.384 | – | – |
| Case-control | 4 | 1.57 (1.25–1.97) | <0.0001 | 0.88 | 0.00 | 0.829 | 0.268 | 0.497 |
| Cohort | 9 | 1.64 (1.45–1.86) | <0.0001 | 15.69 | 49.01 | 0.047 | 0.313 | 0.404 |
| Hysterectomy without oophorectomy | 8 | 1.59 (1.43–1.77) | <0.0001 | 10.19 | 31.32 | 0.178 | 0.585 | 0.621 |
| Self-reported | 6 | 1.65 (1.40–1.95) | <0.0001 | 4.41 | 0.00 | 0.492 | 0.648 | 0.573 |
| Hospital record | 2 | 1.54 (1.27–1.87) | <0.0001 | 5.76 | 82.64 | 0.016 | – | – |
| Case-control | 4 | 1.61 (1.23–2.11) | 0.001 | 2.35 | 0.00 | 0.504 | 0.692 | 0.497 |
| Cohort | 4 | 1.59 (1.38–1.82) | <0.0001 | 7.83 | 61.71 | 0.050 | 0.694 | 1.000 |
| Age at surgery <45 y | 7 | 1.81 (1.51–2.17) | <0.0001 | 6.45 | 6.93 | 0.375 | 0.689 | 0.652 |
| Age at surgery >45 y | 7 | 1.38 (1.13–1.69) | 0.002 | 13.07 | 54.1 | 0.042 | 0.598 | 0.453 |
| Hysterectomy with oophorectomy | 14 | 1.39 (1.16–1.67) | <0.0001 | 22.45 | 42.1 | 0.049 | 0.785 | 0.352 |
| Case-control | 6 | 1.44 (1.04–1.99) | 0.026 | 3.39 | 0.00 | 0.64 | 0.097 | 0.015 |
| Cohort | 8 | 1.34 (1.06–1.70) | 0.013 | 19.06 | 63.27 | 0.008 | 0.161 | 0.216 |
| Hysterectomy-BSOc | 10 | 1.46 (1.19–1.77) | <0.0001 | 17.98 | 49.94 | 0.035 | 0.942 | 0.531 |
| Case-control | 4 | 1.41 (1.00–1.98) | 0.051 | 3.03 | 1.12 | 0.386 | 0.212 | 0.042 |
| Cohort | 6 | 1.45 (1.14–1.85) | 0.003 | 14.83 | 66.28 | 0.011 | 0.501 | 0.573 |
| Hysterectomy-USOd | 4 | 0.99 (0.62–1.57) | 0.967 | 1.76 | 0.00 | 0.623 | 0.069 | 0.174 |
| Case-control | 2 | 1.92 (0.64–5.79) | 0.247 | 0.08 | 0.00 | 0.780 | – | – |
| Cohort | 2 | 0.86 (0.52–1.43) | 0.561 | 0.01 | 0.00 | 0.914 | – | – |
aThe risk estimates were calculated using the random-effects model; bNumber of data used to calculate the risk; cBilateral Salpingo Oophorectomy; dUnilateral Salpingo Oophorectomy.