TABLE 2.
Pharmacokinetic parameters of BDQ and M2 after oral administration of BDQ in mice with or without TBI-166 (mean ± SD, n = 3).
| Parameters (unit) | BDQ (BDQ + TBI-166) | BDQ (BDQ) | M2 (BDQ + TBI-166) | M2 (BDQ) | |
|---|---|---|---|---|---|
| t 1/2 (h) | 106.67 | 215.49 | 57.47 | 64.27 | |
| T max (h) | 3 | 3 | 1 | 3 | |
| C max (ng/mL) | 308.27 ± 24.11 | 349.0 ± 69.5 | 1,235.36 ± 22.74 | 1,438.31 ± 127.21 | |
| AUC(0-last) (h·ng/mL) | 9,971 ± 594 (101%) | 9,843 ± 1,325 (100%) | 76,310 ± 5,901 (66%) | 115,704 ± 19,589 (100%) | |
| AUC(0-∞) (h·ng/mL) | 13,842 | 15,695 | 89,814 | 134,430 | |
| MRT(0-t) (h) | 54.16 | 52.80 | 51.71 | 56.46 | |