Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of TBI-166 after oral administration of BDQ in mice with or without BDQ (mean ± SD, n = 3).
| Parameters (unit) | TBI-166 (BDQ + TBI-166) | TBI-166 (TBI-166) |
|---|---|---|
| t 1/2 (h) | 132.67 | 142.03 |
| T max (h) | 1 | 1 |
| C max (ng/mL) | 709.45 ± 71.13 | 1,043.84 ± 92.53 |
| AUC(0-last) (h·ng/mL) | 62,050 ± 2,519 (91%) | 68,953 ± 4,843 (100%) |
| AUC(0-∞) (h·ng/mL) | 103,720 | 119,114 |
| MRT(0-t) (h) | 65.18 | 66.37 |
