TABLE 3.
Intra-day and inter-day precision and accuracy of almonertinib, apixaban and rivaroxaban in rat plasma.
| Analytes | Concentration (ng/mL) | Intra-day (n = 6) | Inter-day (n = 18) | ||||
|---|---|---|---|---|---|---|---|
| Mean ± SD | RSD (%) | RE (%) | Mean ± SD | RSD (%) | RE (%) | ||
| almonertinib | 0.5 | 0.53 ± 0.04 | 6.7 | 6.47 | 0.51 ± 0.05 | 9.4 | 1.83 |
| 1 | 0.98 ± 0.05 | 5.4 | −2.43 | 0.98 ± 0.08 | 8.1 | −2.05 | |
| 80 | 77.70 ± 3.27 | 4.2 | −2.88 | 79.90 ± 4.51 | 5.6 | −0.13 | |
| 150 | 152.50 ± 4.51 | 3.0 | 1.67 | 148.06 ± 7.37 | 5.0 | −1.30 | |
| apixaban | 1 | 1.03 ± 0.05 | 4.6 | 2.95 | 0.99 ± 0.06 | 5.6 | −0.21 |
| 2 | 2.03 ± 0.05 | 2.7 | 1.67 | 2.04 ± 0.07 | 3.3 | 1.83 | |
| 400 | 407.17 ± 7.41 | 1.8 | 1.79 | 410.72 ± 15.56 | 3.8 | −3.50 | |
| 800 | 808.50 ± 19.38 | 2.4 | 2.13 | 806.83 ± 22.60 | 2.8 | −1.50 | |
| rivaroxaban | 5 | 4.76 ± 0.11 | 2.3 | −4.80 | 4.93 ± 0.22 | 4.4 | 1.29 |
| 10 | 10.47 ± 0.37 | 3.6 | 4.68 | 10.80 ± 0.42 | 3.9 | 8.01 | |
| 800 | 769.00 ± 22.86 | 3.0 | −3.88 | 779.22 ± 32.08 | 4.1 | −2.60 | |
| 1,500 | 1,486.67 ± 52.41 | 3.5 | −0.89 | 1,446.11 ± 85.42 | 5.9 | −3.59 | |