TABLE 4.
Matrix effects and extraction recovery of almonertinib, apixaban and rivaroxaban in rat plasma (n = 6).
| Analytes | Concentration (ng/mL) | Matrix effect | Extraction recovery | ||
|---|---|---|---|---|---|
| Mean ± SD (%) | RSD (%) | Mean ± SD (%) | RSD (%) | ||
| almonertinib | 1 | 92.34 ± 4.94 | 5.4 | 104.56 ± 3.01 | 2.9 |
| 80 | 91.33 ± 4.94 | 5.4 | 100.10 ± 2.00 | 2.0 | |
| 150 | 96.18 ± 1.82 | 1.9 | 96.12 ± 1.54 | 1.6 | |
| apixaban | 2 | 100.38 ± 5.93 | 5.9 | 93.31 ± 3.08 | 3.3 |
| 400 | 102.36 ± 4.56 | 4.5 | 91.01 ± 4.76 | 5.2 | |
| 800 | 108.06 ± 3.34 | 3.1 | 88.40 ± 1.67 | 1.9 | |
| rivaroxaban | 10 | 100.51 ± 1.51 | 1.5 | 99.71 ± 2.65 | 2.7 |
| 800 | 102.65 ± 2.03 | 2.0 | 109.55 ± 1.58 | 1.4 | |
| 1,500 | 96.74 ± 5.78 | 6.0 | 106.73 ± 1.47 | 1.4 | |