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Anti-tumor activity of The-0504 in PaCa44 mouse xenografts treated by two different schedules. (A) Once per week; (B) twice per week. Three consecutive weeks in both cases. All p-values calculated by the Student's t-test. Control vs The-0504 1.9 mg/kg and 6.0 mg/kg: ***p < 0.0001: Control vs Genz-644282 and Genz-644282 vs The-0504 1.9 mg/kg: *p < 0.05. Control vs 3.0 mg/kg: **p < 0.005. Arrows: administrations. Panel B was adapted from Ref. [11].
