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. 2023 Oct 6;9(10):e20770. doi: 10.1016/j.heliyon.2023.e20770

Table 3.

Mean pharmacokinetic parameters after The-0504 injection in rats.

Dose/Analyte Cmax (ng/mL) Tmax (h) AUC(0-inf)
(ng/mL*h)
T1/2 (h)
The-0504, 30 mg/kg in The-05 protein 657,833 0.03333 20,316,400 41.17
The-0504, 60 mg/kg in The-05 protein 1,073,430 0.03333 37,290,300 41.26
Free Genz-644282, 3.0 mg/kg 184 0.3333 983 15.02
The-0504, 3.0 mg/kg in Genz-644282 34,503 0.5 2,124,120 39.50
The-0504, 6.0 mg/kg in Genz-644282 73,713 0.5 3,812,180 48.48

Measured analyte is underlined.