Skip to main content
. 2023 Oct 4;16:1144614. doi: 10.3389/fnmol.2023.1144614

Figure 1.

Figure 1

Inhibition of CCL2 and CFA-induced mechanical hyperalgesia and thermal hyperalgesia by intervertebral foramen injection of ZD7288. (A) Reversal of CFA-induced mechanical hyperalgesia by ZD7288 (100 μM) given 24 h after CFA injection. (B) Reversal of CFA-induced thermal hyperalgesia by ZD7288 (100 μM) given 24 h after CFA injection. (C) Prevention of DRG injection CCL2 (100 ng) – induced mechanical hyperalgesia by ZD7288 (100 μM, 200 μM, intervertebral foramen injection). (D) Reversal of CCL2-induced heat hyperalgesia by ZD7288 (100 μM, 200 μM, intervertebral foramen injection). All data are presented as mean ± SEM. * and + and # p < 0.05, ** and ++, and ## p < 0.01, *** and +++, and ### p < 0.001, **** and ++++, and #### p < 0.0001, n = 9–10 mice/group.